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Polyphenols are substances which might be within most of the plant-based foods we commonly eat. There is also abundant research data suggesting that diets full of certain natural dietary polyphenols could be of the decreased probability of cardiovascular disease, also.
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Hesperidin, which can be a flavonoid polyphenol, is within various plant-based foods, including oranges, orange juice, as well as other citrus fruits. A newly published prospective, randomized, blinded clinical research study, which appears inside current issue with the American Journal of Clinical Nutrition, offers intriguing evidence that hesperidin could actually reduce the likelihood of coronary disease in high-risk patients.
In this pilot study, 24 overweight (but otherwise healthy) men, ages 50 to 65 years, were exposed to 4-week intervals in every one of three experimental groups. The first group was used on drink 500 ml (17 ounces) of orange juice every day.
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The second experimental group drank a “control drink” that appeared similar to orange juice, but which failed to contain any actual orange juice. However, this “sham orange juice” was fortified with hesperidin. The third group was also allotted to drink the fake orange juice, and to which was added sport nutrition portrayed (towards the study volunteers, and also to your research nurses who administered the beverages to those research volunteers) as hesperidin, but which, the truth is, was an inert placebo that contained no hesperidin or any other polyphenols.
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Physical examinations and blood tests were performed before the men rotated through each of these three experimental groups.
The findings with this small but top quality clinical research study were worth it to read. When compared towards the control group that consumed the fake orange juice and fake hesperidin supplement, the men inside the other two experimental groups experienced a tremendous lowering of their numbers. Specifically, the diastolic hypertension was significantly reduced, meaning these men experienced an improvement inside the elasticity, or compliance, of the arteries, as a direct result of the hesperidin found in both orange juice no added sugar and inside the non-juice beverage supplemented with hesperidin.
This observation was again confirmed through additional testing that revealed improved vascular compliance related to hesperidin intake. Moreover, this significant improvement in arterial compliance was observed only following the ingestion of hesperidin, and disappeared when these same men were retested after undergoing an overnight fast. (Improved arterial compliance is of the reduced risk of heart disease, including high blood pressure levels, coronary heart, and stroke.)
To summarize the findings on this study, hesperidin, when taken within the form of either orange juice brands with vitamin d or as sport nutrition, seemed to significantly improve arterial elasticity, reducing diastolic hypertension, in middle-aged overweight men. While this brief study cannot prove that these observed and transient improvements in arterial compliance subsequently reduced the incidence of heart disease during these high-risk men, there is abundant data using their company clinical tests linking improved arterial compliance with a reduced incidence of cardiovascular disease.
A bigger version of the small pilot study should certainly be repeated, as well as the volunteers within this larger study need to be followed to get a much longer duration of time, before we could say, with certainty, that hesperidin significantly reduces the probability of heart disease. That being said, the findings of the small but well-conducted, and chic, randomized, controlled, prospective clinical research study are nevertheless quite compelling.